Neutropenia

Researchers from Washington University, Medical Department publish findings in neutropenia

Published in Clinical Oncology Week, March 24th, 2008

"Purpose of review Severe congenital neutropenia is an inborn disorder of granulopoiesis. Mutations of ELA2, encoding neutrophil elastase, are present in approximately 50% of cases of severe congenital neutropenia and nearly all cases of cyclic neutropenia, a related disorder of granulopoiesis," scientists writing in the journal Current Opinion in Hematology report.

"Herein, we review recent studies of the molecular pathogenesis of severe congenital neutropenia, with an emphasis on those cases associated with mutations of ELA2. Recent findings Genetic evidence suggests that ELA2 mutations act in a dominant, cell-intrinsic fashion to disrupt granulopoiesis. A...

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Source: Clinical Oncology Week (2008-03-24)

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