Colon Cancer
Increased hepcidin expression: A novel oncogenic signalling mechanism
Published in Clinical Oncology Week, March 31st, 2008
Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss. Previous studies have elegantly shown that the anti-microbial peptide hepcidin can also induce anaemia as a consequence of infection and or inflammation. This type of anaemia has been termed anaemia of chronic disease. Thus the primary aim of the recent article by Ward et al published on March 7, 2008 in the World Journal of Gastroenterology was to address whether a component of the anaemia observed in colorectal cancer patients is due to raised hepcidin expression.
Using the technique of mass spectrometry Ward et al clearly demonstrate that whilst circulating hepcidin...
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