Drug Resistance
Reports summarize drug resistance research from Hospital for Sick Children, Department of Pediatric Laboratory Medicine
Published in Clinical Oncology Week, March 31st, 2008
Research findings, 'Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog,' are discussed in a new report. According to a study from Toronto, Canada, "Multidrug resistance (MDR) via the ABC drug transporter (ABCB1), P-glycoprotein (P-gp/MDR1) overexpression, is a major obstacle in cancer chemotherapy. Many inhibitors reverse MDR but, like cyclosporin A (CsA), have significant toxicities."
"MDR1 is also a translocase that flips glucosylceramide inside the Golgi to enhance neutral glycosphingolipid (GSL) synthesis. We observed partial MDR1/globotriaosylceramide (Gb3) cell surface co-localization, and GSL removal depleted cell surface MDR1....
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