RNA Research
New RNA research study findings have been reported by researchers at Catholic University, Department of Oncology
Published in Clinical Oncology Week, April 14th, 2008
A new study, 'Hypoxia induces class III beta-tubulin gene expression by HIF-1alpha binding to its 3' flanking region,' is now available. "Class III beta-tubulin (TUBB3) overexpression represents a major mechanism of drug resistance to microtubule interacting agents such as taxanes and Vinca alkaloids. Here, we tested hypoxia as a possible inducer of TUBB3," scientists writing in the journal Gene report.
"The effects of hypoxia on TUBB3 expression were monitored at mRNA and protein level in A2780, in its paclitaxel-resistant counterpart (TC1) and in HeLa cells. Hypoxia was a strong inducer of TUBB3 in A2780, but not in TC1 and HeLa cells. In A2780 HIF-1alpha was...
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