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Breast Cancer

Breast cancer risk amplified by additional genes in combo with BRCA mutation

Published in Clinical Oncology Week, April 28th, 2008

Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published this month in the American Journal of Human Genetics.

Researchers at the University of Pennsylvania School of Medicine join an international consortium of research groups that looked at more than 10,000 women carrying a BRCA1 or BRCA2 mutation for breast-cancer risk.

"These results suggest that knowledge of a BRCA1 or BRCA2 mutation is necessary, but not sufficient, to fully understand cancer risk in women who carry these mutations," says co-author and head of the North American coalition Timothy R....

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