Pancreas
Findings from University of Basel, Center of Biomedicine in pancreas reported
Published in Clinical Oncology Week, April 28th, 2008
Scientists discuss in 'Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4' new findings in pancreas. According to a study from Basel, Switzerland, "Sprouty (Spry) proteins modulate signal transduction pathways elicited by receptor tyrosine kinases (RTK). Depending on cell type and the particular RTK, Spry proteins exert dual functions: They can either repress RTK-mediated signaling pathways, mainly by interfering with the Ras/Raf/mitogen-activated protein kinase pathway or sustaining RTK signal transduction, for example by sequestering the E3 ubiquitin-ligase c-Cbl and thus preventing ubiquitylation, internalization, and degradation of RTKs."
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