Prostate Cancer

Reports from Malmo University describe recent advances in prostate cancer

Published in Clinical Oncology Week, May 26th, 2008

According to recent research published in the International Journal of Cancer, "Interleukin-6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes and has been implicated in the progression of hormone refractory PCas. In the present study, we characterized the IL6-triggered P13K/Akt and MAPK/Erk signaling."

"We identified the A-type cyclin, cyclin At as an important downstream target of P13K/Akt. Treatment of cells with P13K inhibitor or cotransfection with a vector expressing wild-type PTEN decreased cyclin At promoter activity. Cyclin At promoter activity and its expression were upregulated by constitutively...

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Source: Clinical Oncology Week (2008-05-26)

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