Mammary Tumour Virus

Reports outline mammary tumour virus study findings from P. Bernard and colleagues

Published in Clinical Oncology Week, June 9th, 2008

According to a study from Clayton, Australia, "Background information. During embryonic development, beta-catenin is central both to the transcriptional activation of Wnt [wingless-type MMTV (murine-mammary-tumour virus) integration site family] target genes and as a mediator of cell-cell adhesion."

"Signals that regulate its levels and subcellular localization are critical. One mechanism of Wnt signalling results in stabilization of beta-catenin protein, which leads to its translocation into the nucleus, where it interacts with TCF (T-cell factor, HMG box) and activates transcription of target genes. Less well understood are mechanisms of Wnt signalling that do not...

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Source: Clinical Oncology Week (2008-06-09)

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