Beth Israel Deaconess Medical Center

New insights into the regulation of PTEN tumor suppression function

Published in Clinical Oncology Week, September 1st, 2008

The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated of all tumor suppressors.

Now, a study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School provides important new insights into PTEN regulation. Reported in the August 20 advance on-line issue of Nature, the findings define a pathway that maintains PTEN in the nucleus and offer a novel target for enhancing this gene's tumor...

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Source: Clinical Oncology Week (2008-09-01)

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