Cutaneous T-Cell Lymphoma

Scientists at University of Zurich discuss research in cutaneous t-cell lymphoma

Published in Clinical Oncology Week, September 1st, 2008

"Mycosis fungoides (MF) is the most frequent cutaneous T-cell lymphoma (CTCL). Arsenic trioxide (As2O3) has recently been shown to be effective against leukemias, so we studied whether As2O3 induces apoptosis of CTCL cells in vitro," scientists writing in the journal Annals of Oncology report.

"We further investigated if As2O3 is effective in a MF mouse model. Annexin V/7-amino-actinomycin-D stainings were carried out to investigate if As2O3 induced apoptosis of CTCL cell lines. To study the underlying mechanisms, the effects of As2O3 on various transcription factors and apoptosis regulating proteins were analyzed by western blots, electrophoretic mobility shift...

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Source: Clinical Oncology Week (2008-09-01)

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