Neuroblastoma

Study results from Medical College of Wisconsin, Medical College update understanding of neuroblastoma

Published in Clinical Oncology Week, October 13th, 2008

"Neuroblastomas and many other solid tumors produce high amounts of macrophage migration inhibitory factor (MIF), which appears to play a role in tumor progression. We found that MIF expression in neuroblastoma inhibits T cell proliferation in vitro, raising the possibility that MIF promotes tumorigenesis, in part, by suppressing antitumor immunity," investigators in the United States report.

"To examine whether tumor-derived MIF leads to suppression of T cell immunity in vivo, we generated MIF-deficient neuroblastoma cell lines using short hairpin small interfering RNAs (siRNA). The MIF knockdown (MIFKD) AGN2a neuroblastoma cells were more effectively rejected in...

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Source: Clinical Oncology Week (2008-10-13)

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