Retinoblastoma

Recent findings in retinoblastoma described by researchers from Peking University

Published in Clinical Oncology Week, October 13th, 2008

According to recent research from Beijing, People's Republic of China, "In recent years the anticancer properties of vanadium compounds have been noticed, but the underlying mechanisms are not well understood. In the present work, we found that vanadyl bisacetylacetonate ([VO(acac)(2)]) blocked cell cycle progression permanently at G1 phase in a dose- and time-dependent manner in HepG2 cells."

"This was further evidenced by the growth regulatory signals during the G1 stage. After the treatment with [VO(acac)(2)], the level of phophorylation of retinoblastoma tumor suppressor protein (pRb) and the expressions of cyclin D1, cyclin E and cyclin A were reduced, while the...

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Source: Clinical Oncology Week (2008-10-13)

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