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Nasopharyngeal Carcinoma

New findings in nasopharyngeal carcinoma described from Chang Gung Memorial Hospital, Department of Pathology

Published in Clinical Oncology Week, October 13th, 2008

A new study, 'Transcriptional repression of tissue inhibitor of metalloproteinase-3 by Epstein-Barr virus latent membrane protein 1 enhances invasiveness of nasopharyngeal carcinoma cells,' is now available. "Epstein-Barr virus latent membrane protein 1 (LMP1) has oncogenic and metastasis-promoting activity. We found that LMP1 down-regulated the anti-metastatic protein tissue inhibitor of metalloproteinase-3 (TIMP-3) in EBV-negative nasopharyngeal carcinoma (NPC) cells," scientists in Kaohsiung, Taiwan report.

"Promoter assay demonstrated that LMP1 inhibited TIMP-3 via transcription repression and the response element is located at the -44/+28 region of the TIMP-3...

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