Lung Cancer

New findings in lung cancer described from Emory University, Medical Department

Published in Clinical Oncology Week, October 20th, 2008

"BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is mutated in breast and lung cancers. In this study, we have shown for the first, time that BAPI has tumor suppressor activity in vivo by showing that BAP1 can suppress tumorigenicity of lung cancer cells in athymic nude mice," scientists in the United States report.

"We show that BAP1 fulfills mother criterion of a genuine tumor suppressor because cancer-associated BAP1 mutants are deficient in deubiquitinating activity. We show for the first time that. one of the two predicted nuclear targeting motifs is required for nuclear localization of BAP1 and that a truncation mutant,...

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Source: Clinical Oncology Week (2008-10-20)

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