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World Journal of Gastroenterology

A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found

Published in Clinical Oncology Week, November 10th, 2008

The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. However, alterations of EphA4 are not well understood in gastric cancer.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology will adress this question. This study was conducted by a team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University in...

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