Angiogenesis

New findings from A. Ohradanova and co-researchers in the area of angiogenesis described

Published in Clinical Oncology Week, November 24th, 2008

"Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear," scientists writing in the British Journal of Cancer report.

"As insufficient delivery of oxygen is a driving force of angiogenesis in growing tumours, we investigated whether hypoxia regulates endosialin expression. Here, we demonstrate that endosialin gene transcription is induced by hypoxia predominantly through a mechanism involving hypoxia-inducible factor-2 (HIF-2) cooperating with the Ets-1 transcription...

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Source: Clinical Oncology Week (2008-11-24)

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