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Research from German Cancer Research Center has provided new information about life sciences

Published in Clinical Oncology Week, December 8th, 2008

Data detailed in 'A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells' have been presented. "Dendritic cells (DC) are known to support the activation of natural killer (NK) cells. However, little is known about the role for DC in NK-cell homeostasis," scientists in Heidelberg, Germany report.

"In order to investigate this question, a novel bacterial artificial chromosome transgenic mouse model was generated in which the diphtheria toxin receptor is expressed under the CD11c promoter. In these mice efficient DC depletion can be achieved over prolonged periods of time by...

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