Hepatocellular Cancer

Researchers at University of Duisburg have published new data on hepatocellular cancer

Published in Clinical Oncology Week, January 12th, 2009

"Detection of new biomarkers for hepatocellular carcinoma (HCC) is needed to estimate prognosis after liver transplantation (OLT) or hepatic resection. Osteopontin (OPN) is a secreted, calcium-binding, phosphorylated, acidic glycoprotein that is overexpressed in various cancers," researchers in Essen, Germany report.

"Cluster differentiation 44 standard isoform (CD44s) is one of the primary receptors of OPN; it may contribute to metastatic tumor spread. Tumor tissue and surrounding hepatic parenchyma were obtained from 53 HCC patients who underwent liver resection. Their RNA was extracted from nitrogen-frozen tissues, and OPN mRNA levels were estimated by quantitative...

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Source: Clinical Oncology Week (2009-01-12)

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