Life Sciences
Reports summarize life sciences study results from M.D. Anderson Cancer Center, Department of Experimental Therapeutics
Published in Clinical Oncology Week, January 12th, 2009
Investigators publish new data in the report 'HIF-1 regulation: not so easy come, easy go.' "The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to hypoxia and its expression levels are tightly controlled through synthesis and degradation. It is widely accepted that HIF-1alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway," researchers in the United States report.
"However, recent data describe new pVHL-or oxygen-independent mechanisms for HIF-1alpha degradation. Furthermore, the hypoxia-induced increase in HIF-1alpha levels is...
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