Published in Clinical Oncology Week, January 19th, 2009
"Here we found that BMP-2 directed the migration and increased cell surface and mRNA expression of beta 1 integrin in human chondrosarcoma cancer cells (JJ012). Pretreated of JJ012 cells with phosphatidylinositol 3-kinase inhibitor (P13K; Ly294002) or Akt inhibitor inhibited the BMP-2-mediated migration and integrin expression. BMP-2 increased the...
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