Cancer

Study findings on cancer are outlined in reports from Y.C. Fong and colleagues

Published in Clinical Oncology Week, January 19th, 2009

"Bone morphogenetic protein-2 (BMP-2), a member of transforming growth factor-beta superfamily, plays a crucial role in migration and metastasis of human cancer cells. Integrins are the major adhesive molecules in mammalian cells cancer cells (JJ012)," scientists writing in the Journal of Cellular Physiology report.

"Here we found that BMP-2 directed the migration and increased cell surface and mRNA expression of beta 1 integrin in human chondrosarcoma cancer cells (JJ012). Pretreated of JJ012 cells with phosphatidylinositol 3-kinase inhibitor (P13K; Ly294002) or Akt inhibitor inhibited the BMP-2-mediated migration and integrin expression. BMP-2 increased the...

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Source: Clinical Oncology Week (2009-01-19)

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