Gastric Cancer

New findings from S. Bhargava and co-authors in the area of gastric cancer published

Published in Clinical Oncology Week, January 19th, 2009

" A clinically relevant animal model for cancer of the esophagogastric junction does not exist. This study aimed to establish an orthotopic mouse model for human gastric cancer of the distal stomach and the gastric cardia," researchers in Berlin, Germany report.

"Materials and methods Human gastric cancer cell lines AGS, MKN-45, and NCI-N87 were injected subcutaneously into nude mice. These donor tumors were harvested after 4 weeks and minced into small tumor fragments. One donor tumor fragment was orthotopically implanted into the submucosa of either gastric cardia or distal stomach in other mice. The animals were killed 4, 8, and 12 weeks after tumor implantation....

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Source: Clinical Oncology Week (2009-01-19)

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