Gastrointestinal Stromal Tumors

Research from M.C. Heinrich and co-authors in the area of gastrointestinal stromal tumors published

Published in Clinical Oncology Week, January 19th, 2009

According to a study from the United States, " Imatinib mesylate is standard treatment for patients who have advanced gastrointestinal stromal tumor (GIST), but not all patients benefit equally. In previous studies, GIST genotype correlated with treatment outcome and optimal imatinib dosing."

"Patients and Methods We examined the relationship between kinase genotype and treatment outcome for 428 patients enrolled on the North American phase III study SWOG S0033/CALGB 150105 and treated with either 400 mg or 800 mg daily doses of imatinib. The presence of KIT exon 11-mutant genotype (n = 283) correlated with improved treatment outcome when compared with KIT exon...

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Source: Clinical Oncology Week (2009-01-19)

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