Journal of the National Cancer Institute
Few DNA repair genes maintain association with cancer in field synopsis
Published in Clinical Oncology Week, January 19th, 2009
Variants of numerous DNA repair genes initially appeared to be statistically significantly associated with cancer risk in epidemiological studies. When the data from individual studies are pooled, however, few DNA repair gene variants appear truly associated with increased cancer risk, according to a field synopsis published in the December 30 online issue of the Journal of the National Cancer Institute.
Because DNA damage is associated with cancer development, researchers hypothesized that genes required for DNA repair may influence risk of cancer. Initial reports supported the idea. A comprehensive review of the data has not been available previously.
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