JAMA and Archives Journals

Genetic ID of marker in lymph nodes may be linked to colorectal cancer recurrence risk

Published in Clinical Oncology Week, March 2nd, 2009

A preliminary report suggests that genetic testing may help identify a marker in lymph nodes that is associated with an increased risk of colorectal cancer recurrence among patients in whom conventional testing indicates that those lymph nodes show no evidence of cancer spread, according to a study in the February 18 issue of JAMA.

Metastasis of tumor cells to regional lymph nodes is the single most important prognostic factor in patients with colorectal cancer. Recurrence rates increase from approximately 25 percent in patients with lymph nodes free of tumor cells as determined by biopsy (pN0 colorectal cancer) to approximately 50 percent in patients with four or more...

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Source: Clinical Oncology Week (2009-03-02)

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