Osteosarcoma

New osteosarcoma study findings recently were reported by T. Tsukahara and co-researchers

Published in Clinical Oncology Week, March 2nd, 2009

"Papillomavirus binding factor (PBF) was first identified as a transcription factor regulating the promoter activity of human papillomavirus. We previously demonstrated that PBF is an osteosarcoma-associated antigen and 92% of osteosarcoma tissues express PBF in the nucleus," scientists in Sapporo, Japan report.

"Moreover, PBF-positive osteosarcoma has a significantly poorer prognosis than that with negative expression of PBF. In the present study, we assessed the biological role of PBF in cell survival. Overexpression of PBF induced cell death-mediated lactate dehydrase (LDH) release from 293EBNA cells. Cleaved poly(ADP-ribose) polymerase and active caspase-3 were also...

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Source: Clinical Oncology Week (2009-03-02)

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