Urothelial Cancer

Research by J.C. Chen and colleagues in urothelial cancer provides new insights

Published in Clinical Oncology Week, March 2nd, 2009

"Prostate-specific antigen (PSA) is a 33-kDa serine protease that is secreted by prostatic epithelium and non-prostate tissues. Ectopic expression of PSA has also been reported in a variety of non-prostatic epithelial tumors," investigators in Tainan, Taiwan report.

"Expression of PSA and its clinical implication were examined in a total of 422 cases of primary urothelial carcinoma of the bladder. Cytoplasmic reactivity to PSA was observed in 6 cases (1.4%), with the staining being to a low degree in 3 and a high degree in the remaining 3 cases. Expression of PSA was positively related to multiplicity, large tumors (>= 3 cm) and muscle invasion (>= pT2) (p=0.0008,...

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Source: Clinical Oncology Week (2009-03-02)

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