Published in Clinical Oncology Week, April 13th, 2009
"In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as in oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both a-fetoprotein and hepatocyte-paraffin. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous...
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