Published in Clinical Oncology Week, May 25th, 2009
"To investigate the mechanism underlying the nongenomic action of ER alpha in breast cancer cells, we generated a construct of membrane-targeted ER alpha (memER), an expression vector of ER alpha without the nuclear localizing signal and including instead the membrane-targeting sequence of Src kinase. MemER was stably expressed in human breast cancer MCF-7 cells. Cell migration test and tumorigenic assay in nude mice...
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