Published in Clinical Oncology Week, May 25th, 2009
"We found that the majority of CLL cells expressed significantly reduced LFA-1 due to low beta 2 integrin transcripts. VLA-4 expression was heterogenous but underwent rapid activation by the BM chemokine CXCL12. CLL cells failed to transmigrate across VCAM-1-expressing, ICAM-1-expressing, and CXCL12-expressing endothelium, whereas when LFA-1 expression was regained in subsets...
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