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Myeloma

Studies from University of Bari provide new data on myeloma

Published in Clinical Oncology Week, May 25th, 2009

"Myeloma bone disease (MBD) leads to progressive destruction of the skeleton and is the most severe cause of morbidity in multiple myeloma. Its pathogenetic mechanisms are not fully understood, though the current evidence points to osteoclast (OC) hyperactivity coupled with defective osteoblast function unable to counteract bone resorption," scientists in Bari, Italy report.

"OCs are generated in bone marrow by myeloid progenitors through increased levels of receptor activator of nuclear factor kappa B ligand and M-CSF, whose intracellular pathways propagate signals that activate sequential transcription factors, resulting in the production of major OC enzymes that...

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