Clinical Oncology Week
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Adrenocortical Cancer
Research on adrenocortical cancer detailed by D. Weismann and co-authors
July 13th, 2009
According to recent research published in the Journal of Pathology, "Gene array studies indicated that osteopontin (OPN) mRNA is highly expressed in adrenocortical carcinomas (ACCs). OPN enhances invasiveness, proliferation, and metastasis formation, and is associated with poor survival in some malignant diseases." "Integrin alpha v beta 3 has been shown to mediate OPN effects on invasion. In this study, we demonstrated OPN and integrin alpha v beta 3 expression in normal adrenal glands and benign adenomas, with staining seen exclusively in adrenocortical cells as well as even stronger staining in ACC. Western blot analysis confirmed overexpression of OPN in ACC...
Source: Clinical Oncology Week (2009-07-13)
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