Clinical Oncology Week
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Carcinoma Genetics
New carcinoma genetics research from University of Thessaloniki, Department of Pathology discussed
July 13th, 2009
Research findings, 'Mutational analysis of the BRAF, RAS and EGFR genes in human adrenocortical carcinomas,' are discussed in a new report. According to recent research published in the journal Endocrine-related Cancer, "The serine/threonine kinase B-Raf plays a key role in the Ras/Raf/MEK/ERK pathway that relays extracellular signals for cell proliferation and survival. Several types of human malignancies harbor activating BRAF mutations, most frequently a V600E substitution." "The epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase (TK) receptor that mediates proliferation and survival signaling, is expressed in a wide variety of normal and...
Source: Clinical Oncology Week (2009-07-13)
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