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Papillary Cancer Genetics
University of Yamanashi, Department of Pathology details research in papillary cancer genetics
July 13th, 2009
A report, 'Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas,' is newly published data in Laboratory Investigation. "Thyroid transcription factor-1 (TTF-1), also known as NKX2-1, is a homeodomain containing transcriptional factor identified in thyroid, lung and central nervous system. In the thyroid, TTF-1 is essential for thyroid organogenesis and governs thyroid functions by regulating various thyroid-specific genes," researchers in Yamanashi, Japan report. "We previously demonstrated that most differentiated thyroid neoplasms, including follicular adenomas/carcinomas and papillary carcinomas,...
Source: Clinical Oncology Week (2009-07-13)
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