Prostate Cancer
Investigators at Duke University publish new data on prostate cancer
Published in Clinical Oncology Week, July 20th, 2009
"Binding of activated alpha(2)-macroglobulin to GRP78 on the surface of human prostate cancer cells promotes proliferation by activating signaling cascades. Autoantibodies directed against the activated a2-macroglobulin binding site in the NH2-terminal domain of GRP78 are receptor agonists, and their presence in the sera of cancer patients is a poor prognostic indicator," scientists in the United States report.
"We now show that antibodies directed against the GRP78 COOH-terminal domain inhibit [H-3]thymidine uptake and cellular proliferation while promoting apoptosis as measured by DNA fragmentation, Annexin V assay, and clonogenic assay. These antibodies are receptor...
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