Clinical Oncology Week
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Life Sciences
Research from University of California provides new data about life sciences
August 3rd, 2009
"Cytotoxicity-guided fractionation of the organic extract from a Fijian Lyngbya majuscula led to the discovery of desmethoxymajusculamide C (DMMC) as the active metabolite. Spectroscopic analysis including 1D and 2D NMR, MS/MS, and chemical degradation and derivatization protocols were used to assign the planar structure and stereoconfiguration of this new cyclic depsipeptide," scientists writing in the Journal of Natural Products report. "DMMC demonstrated potent and selective anti-solid tumor activity with an IC50 = 20 nM against the HCT-116 human colon carcinoma cell line via disruption of cellular microfilament networks. A linear form of DMMC was generated by...
Source: Clinical Oncology Week (2009-08-03)
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