Gene Therapy

Research on gene therapy published by scientists at University of Tokyo

Published in Clinical Oncology Week, October 12th, 2009

According to a study from Hongo, Japan, "In regard to gene vectors for cancer gene therapy, their percolation into the tumor tissue should be essential for successful outcome. Here, we studied the tumor penetrability of nonviral vectors (polyplexes) after incubation with the multicellular tumor spheroid (MCTS) models and intratumoral (i.t.) injection into subcutaneous tumors."

"As a result, polyethylene glycolated (PEGylated), core-shell type polyplexes (polyplex micelles) showed facilitated percolation and improved transfection inside the tumor tissue, whereas conventional polyplexes from cationic polymers exhibited limited percolation and localized transfection....

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Source: Clinical Oncology Week (2009-10-12)

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