The Wistar Institute
Wistar researchers show targeting 'normal' cells in tumors slows growth
Published in Clinical Oncology Week, November 30th, 2009
In the Journal of Clinical Investigation published online November 16, they demonstrate the critical role for fibroblast activation protein (FAP), expressed by one type of these so-called "stromal" cells, in promoting tumor growth in mice. Genetically deleting or therapeutically targeting FAP significantly reduced the rate of tumor growth in mice by interrupting or blocking important signaling pathways and biological processes required for tumor growth,...
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