Dana-Farber Cancer Institute

Genes found linked to breast cancer drug resistance could guide future treatment choices

Published in Clinical Oncology Week, February 8th, 2010

BOSTON--Researchers at Dana-Farber Cancer Institute have discovered a gene activity signature that predicts a high risk of cancer recurrence in certain breast tumors that have been treated with commonly used chemotherapy drugs.

Despite their resistance to drugs of the anthracycline class, the breast cancers bearing this gene signature will probably still be vulnerable to other types of chemotherapy agents, say scientists in a letter to be published in Nature Medicine on its Web site and later in a print edition. Thus, the findings could lead to a genetic test of breast cancers to help physicians choose the best initial treatment for an individual patient.

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Source: Clinical Oncology Week (2010-02-08)

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