American Gastroenterological Association

Reliable biomarkers needed for early detection of liver cancer

Published in Clinical Oncology Week, March 8th, 2010

While biomarkers are needed to complement ultrasound in the early detection of hepatocellular carcinoma (HCC; liver cancer), neither des-gamma-carboxy prothrombin (DCP) nor the most widely used biomarker, alpha fetoprotein (AFP), is optimal, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

"Most surprising was the finding that patient demographics influenced both des-gamma-carboxy prothrombin and alpha fetoprotein values, but in opposite directions," said Anna S. Lok, MD, AGAF, of the University of Michigan Medical Center and lead author of the study. "This observation merits further...

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Source: Clinical Oncology Week (2010-03-08)

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