Apoptosis Therapy
Research from University of Lethbridge, Department of Biological Sciences provides new data on apoptosis therapy
Published in Clinical Oncology Week, March 15th, 2010
Investigators publish new data in the report 'Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis.' "Chemoresistant tumors often fail to respond to other cytotoxic treatments such as radiation therapy. The mechanisms of chemo-and radiotherapy cross resistance are not fully understood and are believed to be epigenetic in nature," scientists in Canada report.
"We hypothesize that MCF-7 cells and their doxorubicin-resistant variant MCF-7/DOX cells may exhibit different responses to ionizing radiation due to their dissimilar epigenetic status. Similar to previous studies, we found that MCF-7/DOX...
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