Nucleoside Analogs
New nucleoside analogs data have been reported by S. Curbo and co-authors
Published in Clinical Oncology Week, March 22nd, 2010
"The nucleoside analogs 9-beta-D-arabinofuranosylguanine (araG) and 1-beta-D-arabinofuranosylthymine (araT) are substrates of mitochondrial nucleoside kinases and have previously been shown to be predominantly incorporated into mtDNA of cells, but the pharmacological importance of their accumulation in mtDNA is not known. Here, we examined the role of mtDNA in the response to araG, araT and other anti-cancer and anti-viral agents in a MOLT-4 wild-type (wt) T-lymphoblastoid cell line and its petite mutant MOLT-4 rho(0) cells (lacking mtDNA)," scientists in Stockholm, Sweden report.
"The mRNA levels and activities of deoxyguanosine kinase (dGK), deoxycytidine kinase...
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