Cancer Diagnostics
Research data from Kyushu University, Department of Applied Chemistry update understanding of cancer diagnostics
Published in Clinical Oncology Week, April 12th, 2010
New investigation results, 'Gold nanoparticle-based colorimetric assay for cancer diagnosis,' are detailed in a study published in Biosensors & Bioelectronics. According to a study from Fukuoka, Japan, "A novel gold nanoparticle (GNP)-based colorimetric assay was developed for cancer diagnosis. This system is based on the noncrosslinking aggregation mechanism with a cationic protein kinase C (PKC) alpha-specific peptide substrate, which is used as a coagulant of citrate-coated GNP with anionic surface charges."
"The phosphorylation of peptide substrates by PKCalpha suppressed GNP aggregation, resulting in a red color, but in the case of non-phosphorylation, the...
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