Lymphoma
New lymphoma study findings recently were reported by researchers at University of Texas M.D. Anderson Cancer Center, M.D. Anderson Cancer Center
Published in Clinical Oncology Week, June 14th, 2010
New investigation results, 'SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability,' are detailed in a study published in Oncogene. According to recent research from the United States, "SSBP proteins bind and stabilize transcriptional cofactor LIM domain-binding protein1 (LDB1) from proteosomal degradation to promote tissue-specific transcription through an evolutionarily conserved pathway. The human SSBP2 gene was isolated as a candidate tumor suppressor from a critical region of loss in chromosome 5q14.1."
"By gene targeting, we show increased predisposition to B-cell lymphomas and carcinomas in Ssbp2(-/-) mice. Remarkably, loss of Ssbp2 causes...
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