Stem Cell Research
New stem cell research study findings have been reported from Cancer Research UK London Research Institute
Published in Clinical Oncology Week, June 14th, 2010
A report, 'Spindles losing their bearings: does disruption of orientation in stem cells predict the onset of cancer,' is newly published data in Bioessays. "Recently, Quyn et al. demonstrated that cells within the stem cell zone of human and mouse intestinal crypts tend to align their mitotic spindles perpendicular to the basal membrane of the crypt. This is associated with asymmetric division, whereby particular proteins and individual chromatids are preferentially segregated to one daughter cell," scientists in London, the United Kingdom report.
"In colonic mucosa containing a heterozygous adenomatous polyposis coli gene (APC) mutation the asymmetry is lost....
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