Methyltransferases

Investigators at Kobe University have published new data on methyltransferases

Published in Clinical Oncology Week, June 14th, 2010

According to recent research published in the journal Oncology Reports, "Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de now pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy."

"TAS-102 is a novel drug containing trifluorothymidine, which is phosphorylated by TK-1 to its active monophosphated form, that in turn can inhibit TS. TAS-102 has been shown to exhibit antitumor activity in fluoropyrimidine-resistant human cancer cells. TAS-102 is currently undergoing clinical trials for use in gastrointestinal...

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Source: Clinical Oncology Week (2010-06-14)

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