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Mutation Research

Findings in Mutation Research Reported from Oregon Health & Science University

Published in Clinical Oncology Week, February 21st, 2011

2011 FEB 21 -- New research, 'Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation,' is the subject of a report. According to recent research published in the journal Mutation Research, "A hallmark of aberrant DNA methylation-associated silencing is reversibility. However, long-term stability of reactivated promoters has not been explored."

"To examine this issue, spontaneous reactivant clones were isolated from mouse embryonal carcinoma cells bearing aberrantly silenced Aprt alleles and re-silencing frequencies were determined as long as three months after reactivation occurred. Despite...

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