Neuroblastomas

Data on Neuroblastomas Reported by Researchers at Nihon University

Published in Clinical Oncology Week, September 12th, 2011

2011 SEP 12 -- According to the authors of a study from Tokyo, Japan, "This paper reports the synthesis of methoxy-and bromo-indirubins, and their antiproliferative activities in human neuroblastoma. Among 20 compounds, 5'-methoxyindirubin induced cell death in human neuroblastoma cells (IMR-32, SK-N-SH and NB-39) without inhibiting normal cells (NHDF and HUVEC)."

"Typical morphologic features of apoptosis were observed in 50-methoxyindirubin-treated cells by Hoechst 33342 staining. Additional studies by flow cytometry support apoptosis induction," wrote H. Saito and colleagues, Nihon University.

The researchers concluded: "These data...

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Source: Clinical Oncology Week (2011-09-12)

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