Adenocarcinomas
Findings from Medical University of South Carolina Advance Knowledge in Adenocarcinomas
Published in Clinical Oncology Week, January 2nd, 2012
2012 JAN 2 -- Research findings, "Combined anticancer effects of sphingosine kinase inhibitors and sorafenib," are discussed in a new report. According to the authors of recent research published in the journal Investigational New Drugs, "The pro-apoptotic lipid sphingosine is phosphorylated by sphingosine kinases 1 and 2 (SK1 and SK2) to generate the mitogenic lipid sphingosine-1-phosphate (S1P). We previously reported that inhibition of SK activity delays tumor growth in a mouse mammary adenocarcinoma model."
"Because SK inhibitors and the multikinase inhibitor sorafenib both suppress the MAP kinase pathway, we hypothesized that their combination...
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