Gastroenterology
Reports on Gastroenterology Findings from University of Texas Southwestern Provide New Insights
Published in Clinical Oncology Week, January 16th, 2012
2012 JAN 16 -- Research findings, "Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia," are discussed in a new report. According to the authors of recent research from Dallas, Texas, "mTORC1 is a critical regulator of cell growth that integrates multiple signals and is deregulated in cancer. We previously reported that mTORC1 regulation by hypoxia involves Redd1 and the Tsc1/Tsc2 complex."
"Here we show that Redd1 induction by hypoxia is tissue dependent and that hypoxia signals are relayed to mTORC1 through different pathways in a tissue-specific manner. In the liver, Redd1 induction is...
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