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Squamous Cell Carcinoma

Studies in the Area of Squamous Cell Carcinoma Reported from University of Michigan

Published in Clinical Oncology Week, February 27th, 2012

2012 FEB 27 -- Investigators discuss in "The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma" new findings in Squamous Cell Carcinoma. "Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple aggressive cancers, such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. However, the mechanistic basis of rap1GAP downregulation in cancers is poorly understood," researchers in Ann Arbor, Michigan report.

"By employing an integrative approach, we demonstrate polycomb-mediated repression of rap1GAP that involves Enhancer of Zeste Homolog 2 (EZH2), a...

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